Every Patient. Every Dollar. Protected.
Stop gross-to-net revenue leakage before it happens.
RIS Rx provides real-time GTN Revenue Protection for pharmaceutical manufacturers—ensuring patient affordability dollars reach the right patients while protecting your bottom line.
The Problem
Accumulators, maximizers, and program inefficiencies divert billions of dollars intended for patient affordability every year.
The result:
RIS Rx was built to restore integrity to the GTN process.
- Patients struggle to access therapy
- Manufacturers lose visibility into GTN performance
- Affordability programs fail to reach the patients they were designed to help
Why Copay Vendors Miss It
Traditional copay vendors often miss GTN leakage because their infrastructure was built to process claims and distribute funds, not to monitor how those funds interact with today’s increasingly complex payer dynamics.
#1 - They focus on transaction processing - not net revenue integrity.
#2 - They have limited visibility into Maximizer & Accumulator Programs.
#3 - Data is siloed across PBMs and plans, making it difficult to detect.
#4 - Legacy copay programs are built to react to claims, not built for predictive detection.
Copay vendors are optimized for administration, not revenue protection. In today’s environment — shaped by maximizers, accumulators, and complex PBM economics — that gap in visibility and analytics is where GTN leakage often hides.
Our Proven Impact
3M+
patients supported
$1B+
revenue protected
35K+
transactions tracked daily
150+
unique drug brands tracked
Our Gross-To-Net Solutions
PBM / Payer-based leakage solution
Benefit Patient Solution
Addresses maximizer and accumulator GTN leakage in real-time.
Pharmacy-based leakage solution
Affordability Audit & Assurance
Prevents copay misuse through intelligent, automated pharmacy claim audits.
PAP/Free Goods/Bridge-based solution
PatientGuard 360
Automatically prevents PAP/Free Goods/Bridge-based revenue leakage.
Real-time GTN Revenue Protection for your leading drug brands.
How it Works
Purchase only the products that you need.
Pay based on the dollars you save.
Get support any time from your dedicated, in-house team of experts.
RIS Rx is trusted by the world’s leading pharmaceutical manufacturers.
"We expected addressing GTN leakage to be a cost center. Instead, it became a source of profitability."
- Pharma CFO
"RIS Rx's eBV technology is special and I don't need to micromanage them. They are always on it and always get right back to me."
— Director Vendor Management, Patient Support
"RIS Rx's customer service is outstanding. Their team always made time for us. I would re-implement using them."
— Director of Patient Access
"RIS Rx's flexibility and technology are great. They resolved issues with our prior vendor."
— VP of Commercial Operations
Get My GTN Savings Snapshot
Most manufacturers cannot see GTN leakage until it has already impacted their programs.
RIS Rx helps you identify—and prevent—it in real time. We recover hundreds of millions in lost revenue for our customers every year.
Give us 30 minutes and discover how we can do the same for you.
"We expected addressing GTN leakage to be a cost center. Instead, it became a source of profitability."
- Pharma CFO
20+
of the world's leading pharmaceutical manufacturers trust RIS Rx
150+
leading drug brands across all therapeutic areas
100
Net Promoter Score
RIS Rx offers real-time GTN Revenue Protection to the world's leading pharmaceutical manufacturers, ensuring that every dollar allocated for affordability reaches the right patient at the right time.
Billions in GTN Leakage Are Hiding in Plain Sight
The RIS Rx Approach
Real-Time GTN Revenue Protection
RIS Rx identifies and prevents GTN leakage before it happens—not months later in a retrospective audit.
Our pharmacist-led platform helps manufacturers detect, prevent, and quantify leakage across the patient affordability ecosystem in real time.
